Combinatorial control of gene expression

Nat Struct Mol Biol. 2004 Sep;11(9):812-5. doi: 10.1038/nsmb820.

Abstract

Revealing the molecular principles of eukaryotic transcription factor assembly on specific DNA sites is pivotal to understanding how genes are differentially expressed. By analyzing structures of transcription factor complexes bound to specific DNA elements we demonstrate how protein and DNA regulators manage gene expression in a combinatorial fashion.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA / chemistry
  • DNA / genetics*
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Dimerization
  • Gene Expression Regulation*
  • HMGB Proteins
  • Humans
  • Models, Genetic
  • Models, Molecular
  • Nuclear Proteins / metabolism
  • Octamer Transcription Factor-1
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary
  • SOXB1 Transcription Factors
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • HMGB Proteins
  • Nuclear Proteins
  • Octamer Transcription Factor-1
  • POU2F1 protein, human
  • SOX2 protein, human
  • SOXB1 Transcription Factors
  • Transcription Factors
  • DNA