Abstract
[reaction: see text] Novel highly functionalized dipeptide isosters are synthesized via a diastereoselective alkyl/arylation protocol of a glucose-derived (R)-tert-butanesulfinylimine. One of these novel sugar amino acid derivatives, a D-Ala-Ser/Thr isostere, was applied in a peptide synthesis protocol to afford a cyclic tetramer.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acids / chemistry*
-
Catalysis
-
Cyclization
-
Dipeptides / chemical synthesis*
-
Dipeptides / chemistry
-
Indicators and Reagents
-
Molecular Structure
-
Peptides, Cyclic / chemical synthesis*
-
Peptides, Cyclic / chemistry
-
Stereoisomerism
-
Sugar Acids / chemistry*
Substances
-
Amino Acids
-
Dipeptides
-
Indicators and Reagents
-
Peptides, Cyclic
-
Sugar Acids