Abstract
The characteristics of the actions of the non-competitive blocker of NMDA receptors dizocilpine on the expression of the early c-fos gene in the paraventricular nuclei of the hypothalamus were studied in rats with different predicted susceptibilities to emotional stress in conditions of treatment with delta sleep-inducing peptide. The results showed that prior treatment with dizocilpine blocked reductions in c-fos expression induced by delta sleep peptide.
MeSH terms
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Animals
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Delta Sleep-Inducing Peptide / pharmacology
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Delta Sleep-Inducing Peptide / physiology*
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Dizocilpine Maleate / pharmacology*
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Gene Expression Regulation
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Genetic Predisposition to Disease
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Injections, Intraperitoneal
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Injections, Intraventricular
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Male
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Paraventricular Hypothalamic Nucleus / drug effects
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Paraventricular Hypothalamic Nucleus / metabolism*
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Proto-Oncogene Proteins c-fos / biosynthesis*
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Proto-Oncogene Proteins c-fos / genetics
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Rats
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Rats, Wistar
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
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Stress, Psychological / genetics
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Stress, Psychological / metabolism
Substances
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Proto-Oncogene Proteins c-fos
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Receptors, N-Methyl-D-Aspartate
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Delta Sleep-Inducing Peptide
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Dizocilpine Maleate