Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya

Abigael Mbaisi; Pamela Liyala; Fredrick Eyase; Rachel Achilla; Hosea Akala; Julia Wangui; Josphat Mwangi; Finnley Osuna; Uzma Alam; Bonnie L Smoak; Jon M Davis; Dennis E Kyle; Rodney L Coldren; Carl Mason; Norman C Waters

doi:10.1128/AAC.48.9.3598-3601.2004

Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya

Antimicrob Agents Chemother. 2004 Sep;48(9):3598-601. doi: 10.1128/AAC.48.9.3598-3601.2004.

Authors

Abigael Mbaisi¹, Pamela Liyala, Fredrick Eyase, Rachel Achilla, Hosea Akala, Julia Wangui, Josphat Mwangi, Finnley Osuna, Uzma Alam, Bonnie L Smoak, Jon M Davis, Dennis E Kyle, Rodney L Coldren, Carl Mason, Norman C Waters

Affiliation

¹ U.S. Army Medical Research Unit, Nairobi, Kenya.

Abstract

The drug resistance profiles of Plasmodium falciparum isolated from four regions in Kenya were analyzed for drug resistance profiles. We observed variability in resistance to a broad range of antimalarial drugs across Kenya as determined from in vitro drug susceptibility screening and genotyping analysis.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Antimalarials / pharmacology*
Drug Resistance
Genes, Protozoan / genetics
Genotype
Humans
Kenya / epidemiology
Malaria, Falciparum / epidemiology
Malaria, Falciparum / parasitology*
Molecular Epidemiology
Mutation / genetics
Pharmacoepidemiology
Plasmodium falciparum / drug effects*
Plasmodium falciparum / genetics*

Substances

Antimalarials