This paper presents a Decision Support System (DSS) approach developed in the context of the Copernicus project entitled System for Water Monitoring and Sustainable Management based on Ground Stations and Satellite Images (WATERMAN). The main objective of WATERMAN is the monitoring and management of the Strymon River in the Southern Balkans. The specific DSS integrates the main components of WATERMAN and helps the decision maker to monitor the Strymon region; to control and forecast the quantity and quality of the river water; as well as to make objective decisions about the state of the water based on data provided by radio computers, earth stations and satellite images processed by mathematical and statistical models and Geographical Information Systems (GIS).