Abstract
Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Helminth / blood
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Humans
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Papio
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Parasite Egg Count
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Schistosoma / immunology*
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Schistosoma / isolation & purification
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Schistosomiasis / immunology
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Schistosomiasis / parasitology*
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Schistosomiasis / prevention & control*
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Vaccination
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Vaccines, Attenuated / administration & dosage*
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Vaccines, Attenuated / immunology*
Substances
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Antibodies, Helminth
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Vaccines, Attenuated