Abstract
We performed microarray analyses of murine peritoneal macrophages to examine cellular transcriptional responses to a cytotoxic enterotoxin of Aeromonas hydrophila. While 66% of altered genes were common to both primary macrophages and the murine macrophage cell line RAW 264.7, Act caused expression changes of 28 genes specifically in murine peritoneal macrophages.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aeromonas hydrophila / metabolism*
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Animals
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Bacterial Proteins / pharmacology*
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Cell Line
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Cells, Cultured
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Enterotoxins / pharmacology*
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Gene Expression Regulation*
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Macrophages, Peritoneal / drug effects*
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Mice
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Oligonucleotide Array Sequence Analysis / methods*
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Proteins / genetics
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Proteins / metabolism*
Substances
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Bacterial Proteins
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Enterotoxins
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Proteins
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cytolytic enterotoxin protein, Aeromonas