Microarray analysis of Aeromonas hydrophila cytotoxic enterotoxin-treated murine primary macrophages

Infect Immun. 2004 Sep;72(9):5439-45. doi: 10.1128/IAI.72.9.5439-5445.2004.

Abstract

We performed microarray analyses of murine peritoneal macrophages to examine cellular transcriptional responses to a cytotoxic enterotoxin of Aeromonas hydrophila. While 66% of altered genes were common to both primary macrophages and the murine macrophage cell line RAW 264.7, Act caused expression changes of 28 genes specifically in murine peritoneal macrophages.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aeromonas hydrophila / metabolism*
  • Animals
  • Bacterial Proteins / pharmacology*
  • Cell Line
  • Cells, Cultured
  • Enterotoxins / pharmacology*
  • Gene Expression Regulation*
  • Macrophages, Peritoneal / drug effects*
  • Mice
  • Oligonucleotide Array Sequence Analysis / methods*
  • Proteins / genetics
  • Proteins / metabolism*

Substances

  • Bacterial Proteins
  • Enterotoxins
  • Proteins
  • cytolytic enterotoxin protein, Aeromonas