A case of prolonged seizure activity after combined use of bupropion and clomipramine

Clin Neuropharmacol. 2004 Jul-Aug;27(4):192-4. doi: 10.1097/01.wnf.0000135479.78529.60.

Abstract

A case is reported of seizure development after combined use of bupropion and clomipramine. Electroencephalography revealed frequent generalized spike and wave complexes prominent on both frontal areas. These newly developed epileptiform discharges persisted even after discontinuation of both drugs.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antidepressive Agents / adverse effects*
  • Bupropion / adverse effects*
  • Clomipramine / adverse effects*
  • Drug Therapy, Combination
  • Electroencephalography / drug effects
  • Electroencephalography / methods
  • Female
  • Humans
  • Schizophrenia / drug therapy
  • Seizures / etiology*

Substances

  • Antidepressive Agents
  • Bupropion
  • Clomipramine