Ruthenium-catalyzed [3 + 2] intramolecular cycloaddition of alk-5-ynylidenecyclopropanes promoted by the "first-generation" Grubbs carbene complex

Fernando López; Alejandro Delgado; J Ramón Rodríguez; Luis Castedo; José L Mascareñas

doi:10.1021/ja0480466

Ruthenium-catalyzed [3 + 2] intramolecular cycloaddition of alk-5-ynylidenecyclopropanes promoted by the "first-generation" Grubbs carbene complex

J Am Chem Soc. 2004 Aug 25;126(33):10262-3. doi: 10.1021/ja0480466.

Authors

Fernando López¹, Alejandro Delgado, J Ramón Rodríguez, Luis Castedo, José L Mascareñas

Affiliation

¹ Departamento de Química Orgánica, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

PMID: 15315436
DOI: 10.1021/ja0480466

Abstract

The well-known "first generation" Grubbs metathesis complex is capable of catalyzing the intramolecular [3 + 2] cycloaddition of alk-5-ynylidenecyclopropanes. It appears that the species responsible for the catalysis is a ruthenium complex generated in situ from the Grubbs carbene in the presence of the substrate.