In vitro delivery of doxycycline hydrochloride based on a porous membrane-based aqueous-organic partitioning system

J Control Release. 2004 Aug 27;98(3):355-65. doi: 10.1016/j.jconrel.2004.05.005.

Abstract

This work investigated the controlled release of an antibiotic drug, doxycycline HCl, from its solution/suspension in an organic solvent in a reservoir through a porous membrane employing aqueous-organic partitioning with or without a mouse skin to simulate a skin patch. The reservoir contained the agent in solution in the solvent 1-octanol or its dispersion/solution in the solvent mineral oil with or without an enhancer. The porous membranes employed with water-in-pores were hydrophobic Celgard 2400 of polypropylene and hydrophilized polyvinylidene fluoride (PVDF). Conventional Franz diffusion cells as well as a skin patch were used. The transport rates of the agent observed through both Celgard and PVDF membranes could be successfully described by Fickian diffusion through the water-filled pores when the appropriate organic-aqueous partition coefficient was incorporated. The light mineral oil-based system yielded much higher permeability due to the much lower organic-aqueous partition coefficient of the antibiotic in light mineral oil. The optimized skin patch systems yielded drug flux and permeability values similar to their relevant membrane systems. The addition of a mouse skin beneath the patch drastically reduced the drug transfer rate. Among a number of enhancers used to correct this deficiency, linoleic acid at 10% level in the reservoir solution was found to yield a flux of 2.7 +/- 0.5 microg/cm(2) h and a permeability of 2.7e - 04 +/- 5.0e - 05 cm/h. These values are higher than the values available in literature obtained with full thickness human cadaver skin.

MeSH terms

  • Alzheimer Disease
  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Delayed-Action Preparations
  • Diffusion
  • Doxycycline / administration & dosage*
  • Drug Delivery Systems
  • In Vitro Techniques
  • Linoleic Acid / chemistry
  • Male
  • Membranes, Artificial
  • Mice
  • Mice, Hairless
  • Mineral Oil
  • Octanols / chemistry
  • Permeability
  • Polypropylenes
  • Skin Absorption
  • Solutions

Substances

  • Anti-Bacterial Agents
  • Delayed-Action Preparations
  • Membranes, Artificial
  • Octanols
  • Polypropylenes
  • Solutions
  • Mineral Oil
  • Linoleic Acid
  • Doxycycline