[Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy]

Wei Huang; Lin Wang; Ming Yuan; Ji-xian Ma; Yan-nian Hui

[Expression of adrenomedullin and adrenomedullin receptor in the epiretinal membranes of proliferative vitreoretinopathy]

Zhonghua Yan Ke Za Zhi. 2004 May;40(5):317-20.

[Article in Chinese]

Authors

Wei Huang¹, Lin Wang, Ming Yuan, Ji-xian Ma, Yan-nian Hui

Affiliation

¹ Institute of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

PMID: 15312626

Abstract

Objective: To investigate the expression of adrenomedullin (ADM) and ADM receptor (ADMR) in epiretinal membranes (ERM) of proliferative vitreoretinopathy (PVR).

Methods: The expression of ADM and ADMR in 10 ERM were studied by in situ hybridization analysis (ISH).

Results: ADM and ADMR mRNAs were expressed in 7 of 10 specimens. The positive signals were distributed unevenly in positive cells. Some cells expressed mainly in the cytoplasm and the others expressed mainly in the nucleus.

Conclusion: ADM and ADMR are expressed in the ERM of PVR, indicating that ADM and ADMR may play a role in the pathogenesis of PVR.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Adrenomedullin / metabolism*
Humans
RNA, Messenger / biosynthesis
Receptors, Adrenomedullin
Receptors, Peptide / biosynthesis*
Receptors, Peptide / genetics
Retina / metabolism*
Retina / pathology
Vitreoretinopathy, Proliferative / metabolism*
Vitreoretinopathy, Proliferative / pathology

Substances

RNA, Messenger
Receptors, Adrenomedullin
Receptors, Peptide
Adrenomedullin