1 State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, China.
Starting from readily available carbohydrates the synthesis of 8-epi-(+)-boronolide 19 and (+)-boronolide was achieved with diastereoselective propargylation of alpha-oxygenated aldehyde as a key step.