Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells

Chem Pharm Bull (Tokyo). 2004 Aug;52(8):935-7. doi: 10.1248/cpb.52.935.

Abstract

A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Cell Differentiation / drug effects*
  • Erythroblasts / chemistry
  • Erythroblasts / cytology
  • Erythroblasts / drug effects*
  • Hemoglobins / metabolism
  • Humans
  • K562 Cells
  • Porifera / chemistry*
  • Quinones / chemistry
  • Quinones / isolation & purification*
  • Quinones / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Hemoglobins
  • Quinones
  • Sesquiterpenes