Molecular biology: what ubiquitin can do for transcription

Curr Biol. 2004 Aug 10;14(15):R622-4. doi: 10.1016/j.cub.2004.07.046.

Abstract

Ubiquitin, the peptide 'tag' that targets eukaryotic proteins for degradation by the proteasome, has also been implicated in transcriptional activation. The mechanism of gene activation might include recruitment of a transcriptional elongation factor by ubiquitinated activators.

Publication types

  • Comment
  • Review

MeSH terms

  • Models, Biological*
  • Positive Transcriptional Elongation Factor B / metabolism*
  • RNA Polymerase II / metabolism*
  • Transcriptional Activation / physiology*
  • Ubiquitin / metabolism*
  • Ubiquitin / physiology

Substances

  • Ubiquitin
  • Positive Transcriptional Elongation Factor B
  • RNA Polymerase II