Telomeres: not all breaks are equal

Curr Biol. 2004 Aug 10;14(15):R613-4. doi: 10.1016/j.cub.2004.07.042.

Abstract

ATM, Rad50 and Mre11 have been shown to prevent telomere fusion in Drosophila, thereby extending the protective role of DNA damage checkpoint proteins to non-canonical telomeres formed without telomerase. How do these proteins help chromosomal termini escape fusion through 'repair' while promoting repair of induced DNA breaks?

Publication types

  • Review

MeSH terms

  • Acid Anhydride Hydrolases
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / metabolism
  • Chromosomal Instability*
  • DNA Damage / physiology
  • DNA Repair Enzymes / metabolism
  • DNA Repair*
  • DNA-Binding Proteins / metabolism
  • Protein Serine-Threonine Kinases / metabolism
  • Telomerase / metabolism
  • Telomere / metabolism*
  • Telomere-Binding Proteins / metabolism*
  • Tumor Suppressor Proteins

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Telomere-Binding Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein Serine-Threonine Kinases
  • Telomerase
  • Acid Anhydride Hydrolases
  • RAD50 protein, human
  • DNA Repair Enzymes