Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation

Shuichi Machida; Frank W Booth

doi:10.1079/PNS2004354

Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation

Proc Nutr Soc. 2004 May;63(2):337-40. doi: 10.1079/PNS2004354.

Authors

Shuichi Machida¹, Frank W Booth

Affiliation

¹ Department of Biomedical Sciences, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA.

PMID: 15294052
DOI: 10.1079/PNS2004354

Abstract

Insulin-like growth factor 1 (IGF-1) has been shown to rescue the aging-related or inactivity-induced loss of muscle mass through the activation of satellite cells. However, the signalling pathways and the mechanism by which IGF-1 affects satellite cells have not been not completely identified. The purpose of the present review is to provide current understanding of the cellular and molecular events underlying IGF-1 induced proliferation of satellite cells.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Aging / physiology
Cell Division / drug effects
Cells, Cultured
Humans
Insulin-Like Growth Factor I / pharmacology
Insulin-Like Growth Factor I / physiology*
Muscle, Skeletal / cytology*
Muscle, Skeletal / metabolism
Muscle, Skeletal / physiology
Satellite Cells, Skeletal Muscle / drug effects
Satellite Cells, Skeletal Muscle / physiology*

Substances

Insulin-Like Growth Factor I

Grants and funding

AG-18780/AG/NIA NIH HHS/United States