Abstract
The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2-chloro-1, 8-naphthyridines. The synthesized 6H-indolo[2, 3-b][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Division / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Indicators and Reagents
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Indoles / chemical synthesis*
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Indoles / pharmacology*
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Magnetic Resonance Spectroscopy
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Naphthyridines / chemical synthesis*
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Naphthyridines / pharmacology*
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Structure-Activity Relationship
Substances
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6H-indolo(2, 3-b)(1, 8)naphthyridine
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Antineoplastic Agents
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Indicators and Reagents
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Indoles
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Naphthyridines