Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin

Eur J Hum Genet. 2004 Nov;12(11):949-54. doi: 10.1038/sj.ejhg.5201239.

Abstract

Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value = 9.8 x 10(-5)). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Female
  • Gene Frequency
  • Genetic Linkage
  • Humans
  • Integrin beta3 / genetics*
  • Lod Score
  • Male
  • Microsatellite Repeats
  • Pedigree
  • Quantitative Trait Loci*
  • Serotonin / blood*

Substances

  • ITGB3 protein, human
  • Integrin beta3
  • Serotonin