The objective of this study was to evaluate the effectiveness of an educational program in teaching enrollees of an MCO to manage their medical conditions and consequently improve their quality of life. Treatment and control groups were evaluated before entering the program and after completing it. Statistically significant improvements for participants were found in five areas: (1) health distress, (2) self-rated general health, (3) illness intrusiveness, (4) self-efficacy, and (5) activities limitation.