Gastrointestinal autonomic nerve tumours are an uncommon form of gastrointestinal stromal tumours. Since both gastrointestinal stromal tumours and gastrointestinal autonomic nerve tumours are potentially malignant, radical surgical excision is always required. We report a case of a gastrointestinal nerve tumour measuring about 5 cm in diameter and arising from the medial wall of the second portion of the duodenum about 1.5 cm below the papilla of Vater. Because of this rare location a very invasive procedure (duodenocephalo-pancreatectomy) might have been required for tumour resection. We avoided this operation and implemented an alternative solution. Endoscopic ultrasonography was very helpful for this purpose, revealing that the tumour was confined within the duodenal wall and separated from the papilla. We employed a non-conventional surgical technique consisting in a duodenal resection comprising the tumour and a direct TT anastomosis of the duodenal stumps. Two technical devices were of fundamental importance for carrying out this procedure: (i) Ligasure which made dissection between the pancreatic head and duodenal wall a safe manoeuvre with little bleeding; and (ii) Valtrac, which allowed us to perform a large anastomosis without any tension on the duodenal stumps. Intraoperative endoscopy was also important. No anastomotic leakage occurred. At follow-up at 12 months the patient is in good health and CT scan and endoscopic ultrasonography have shown no recurrence of disease.