A new oral anticoagulant: the 50-year challenge

Nat Rev Drug Discov. 2004 Aug;3(8):649-59. doi: 10.1038/nrd1466.
No abstract available

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Anticoagulants* / chemistry
  • Anticoagulants* / pharmacokinetics
  • Anticoagulants* / therapeutic use
  • Area Under Curve
  • Azetidines* / chemistry
  • Azetidines* / pharmacokinetics
  • Azetidines* / therapeutic use
  • Benzylamines
  • Biological Availability
  • Blood Coagulation / physiology*
  • Humans
  • Intestinal Absorption
  • Prodrugs / chemistry
  • Prodrugs / metabolism
  • Prodrugs / therapeutic use
  • Structure-Activity Relationship
  • Thrombosis / drug therapy*

Substances

  • Anticoagulants
  • Azetidines
  • Benzylamines
  • Prodrugs
  • ximelagatran