Synthesis and antiviral activities of new pyrazolo[4,3-c]quinolin-3-ones and their ribonucleoside derivatives

Nucleosides Nucleotides Nucleic Acids. 2004 May;23(5):735-48. doi: 10.1081/NCN-120038009.

Abstract

Several new pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-g) and their corresponding heterocycle moieties (3a-g) were synthesized and evaluated against vaccinia virus (VV) and herpes simplex virus type 1 (HSV-1). The derivatives 3c and 3d showed modest inhibitory activity against vaccinia virus reaching 70% at a concentration of 100 microM. All heterocyclic compounds (3a-f) showed a modest inhibition against HSV-1, reaching the maximal inhibitory effect around 20-30%. The antiviral effects of most of the pyrazolo[4,3-c]quinolin-3-one ribonucleosides (5a-f) on VV and HSV were not impressive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Herpesvirus 1, Human / drug effects
  • Humans
  • Pyrazoles / chemistry
  • Pyrazoles / pharmacology*
  • Quinolines / chemistry
  • Quinolines / pharmacology*
  • Ribonucleosides / chemical synthesis*
  • Ribonucleosides / pharmacology*
  • Vaccinia virus / drug effects
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Pyrazoles
  • Quinolines
  • Ribonucleosides