Abstract
The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters / antagonists & inhibitors
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ATP-Binding Cassette Transporters / metabolism*
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Anti-Infective Agents / metabolism*
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Anti-Infective Agents / pharmacology
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Calcium Channel Blockers / pharmacology
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Ciprofloxacin / pharmacology
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DNA Primers
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Drug Resistance
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Energy Metabolism / drug effects
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Fluoroquinolones / metabolism*
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Gene Expression Regulation, Bacterial / genetics
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Hydrazones / pharmacology
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Mycobacterium smegmatis / genetics
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Mycobacterium smegmatis / metabolism
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / metabolism*
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Operon / genetics
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Reserpine / pharmacology
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Verapamil / pharmacology
Substances
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ATP-Binding Cassette Transporters
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Anti-Infective Agents
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Calcium Channel Blockers
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DNA Primers
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Fluoroquinolones
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Hydrazones
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carbonyl 3-chlorophenylhydrazone
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Ciprofloxacin
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Reserpine
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Verapamil