A 68-year-old man with multiple liver metastases from stage 4 advanced descending colon cancer who underwent partial resection of the colon and simultaneous catheter insertion into the gastroduodenal artery for arterial infusion chemotherapy. On postoperative day 3, the multiple liver metastases had enlarged so rapidly that there was high risk of liver failure. Intraarterial infusion of 5-FU 600 mg/m2 (1,000 mg/body) for 6 hours weekly and intravenous administration of methylpredonisolone 125 mg were started for emergency chemotherapy on the third postoperative day. Only 1 course was sufficient for the patient be rid of oncologic emergencies and liver failure. After 3 courses, liver metastases showed significant reduction.