Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major

Helton da Costa Santiago; Carolina Ferreira Oliveira; Luciana Santiago; Fernanda Oliveira Ferraz; Daniele da Glória de Souza; Luiz Antônio Rodrigues de-Freitas; Luís Carlos Crocco Afonso; Mauro Martins Teixeira; Ricardo Tostes Gazzinelli; Leda Quercia Vieira

doi:10.1128/IAI.72.8.4918-4923.2004

Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major

Infect Immun. 2004 Aug;72(8):4918-23. doi: 10.1128/IAI.72.8.4918-4923.2004.

Authors

Helton da Costa Santiago¹, Carolina Ferreira Oliveira, Luciana Santiago, Fernanda Oliveira Ferraz, Daniele da Glória de Souza, Luiz Antônio Rodrigues de-Freitas, Luís Carlos Crocco Afonso, Mauro Martins Teixeira, Ricardo Tostes Gazzinelli, Leda Quercia Vieira

Affiliation

¹ Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.

Abstract

The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chemokine CCL5 / metabolism*
Leishmania major*
Leishmaniasis, Cutaneous / immunology*
Leishmaniasis, Cutaneous / parasitology
Leishmaniasis, Cutaneous / physiopathology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL

Substances

Chemokine CCL5