Further membranolide diterpenes from the antarctic sponge dendrilla membranosa

J Nat Prod. 2004 Jul;67(7):1172-4. doi: 10.1021/np0340551.

Abstract

Chemical investigation of the Antarctic sponge Dendrilla membranosa collected from the vicinity of Palmer Station on Anvers Island, Antarctica, yielded three new diterpenes, membranolides B-D (2-4), as well as three previously reported sponge metabolites. Membranolides C and D (3, 4), bearing carboxylic acid functional groups, display Gram-negative antibiotic and antifungal activities.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antarctic Regions
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Gram-Negative Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Diterpenes
  • membranolide B
  • membranolide C
  • membranolide D