Nuclear survivin as a biomarker for non-small-cell lung cancer

Br J Cancer. 2004 Aug 2;91(3):537-40. doi: 10.1038/sj.bjc.6602027.

Abstract

Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Apoptosis
  • Biomarkers, Tumor / analysis*
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Cell Nucleus / chemistry*
  • Cysteine Proteinase Inhibitors / analysis*
  • Cytoplasm / chemistry
  • Female
  • Humans
  • Immunohistochemistry
  • Inhibitor of Apoptosis Proteins
  • Lung Neoplasms / pathology*
  • Male
  • Microtubule-Associated Proteins / analysis*
  • Middle Aged
  • Neoplasm Proteins
  • Prognosis
  • Retrospective Studies
  • Survival Analysis
  • Survivin

Substances

  • BIRC5 protein, human
  • Biomarkers, Tumor
  • Cysteine Proteinase Inhibitors
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins
  • Neoplasm Proteins
  • Survivin