Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

Bioorg Med Chem. 2004 Aug 15;12(16):4423-9. doi: 10.1016/j.bmc.2004.06.009.

Abstract

This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / toxicity*
  • Apoptosis*
  • Dracaena / chemistry*
  • HL-60 Cells
  • Humans
  • Poly(ADP-ribose) Polymerases / metabolism
  • Saponins / chemistry*
  • Saponins / isolation & purification
  • Saponins / pharmacology
  • Saponins / toxicity*
  • Steroids / chemistry*
  • Steroids / isolation & purification
  • Steroids / toxicity*

Substances

  • Antineoplastic Agents, Phytogenic
  • Icogenin
  • Saponins
  • Steroids
  • Poly(ADP-ribose) Polymerases