Abstract
This paper reports on the cytotoxic effect induced by a new natural steroidal saponin, icogenin, on the myeloid leukemia cell line HL-60. Icogenin was found to be a cytotoxic compound IC(50) 2.6+/-0.9microM at 72h, with growth inhibition caused by the induction of apoptosis, as determined by microscopy of nuclear changes and the fragmentation of poly(ADP-ribose) polymerase-1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity*
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Apoptosis*
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Dracaena / chemistry*
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HL-60 Cells
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Humans
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Poly(ADP-ribose) Polymerases / metabolism
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Saponins / chemistry*
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Saponins / isolation & purification
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Saponins / pharmacology
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Saponins / toxicity*
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Steroids / chemistry*
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Steroids / isolation & purification
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Steroids / toxicity*
Substances
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Antineoplastic Agents, Phytogenic
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Icogenin
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Saponins
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Steroids
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Poly(ADP-ribose) Polymerases