Abstract
In this study, eight new omega-(1H-imidazol-1-yl)-N-phenylacetamide and propionamide derivatives having 2,6-dimethyl, 2,6-dichloro, 2-chloro-6-methyl and 2-isopropyl substitutions on N-phenyl ring were synthesized to evaluate anticonvulsant activity against maximal electroshock test. The most active compounds in the series were the derivatives bearing 2-isopropyl and 2,6-dimethyl substituents on N-phenyl ring.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetamides / chemical synthesis*
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Acetamides / chemistry
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Acetamides / pharmacology*
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Amides / chemical synthesis*
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Amides / chemistry
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Amides / pharmacology*
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Animals
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Anticonvulsants / chemical synthesis*
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Anticonvulsants / chemistry
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Anticonvulsants / pharmacology*
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Drug Evaluation, Preclinical
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Electroshock
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Molecular Structure
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Seizures / prevention & control*
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Structure-Activity Relationship
Substances
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Acetamides
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Amides
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Anticonvulsants