Cytotoxic constituents from Plumbago zeylanica

A T Nguyen; H Malonne; P Duez; R Vanhaelen-Fastre; M Vanhaelen; J Fontaine

doi:10.1016/j.fitote.2004.03.009

Cytotoxic constituents from Plumbago zeylanica

Fitoterapia. 2004 Jul;75(5):500-4. doi: 10.1016/j.fitote.2004.03.009.

Authors

A T Nguyen¹, H Malonne, P Duez, R Vanhaelen-Fastre, M Vanhaelen, J Fontaine

Affiliation

¹ Laboratoire de Physiologie et de Pharmacologie Fondamentales, Institut de Pharmacie CP-205/7, Université Libre de Bruxelles, B-1050 Brussels, Belgium. annhthng@ulb.ac.be

PMID: 15261389
DOI: 10.1016/j.fitote.2004.03.009

Abstract

The bioassay-guided fractionation of the dichloromethane extract of aerial parts of Plumbago zeylanica led to the isolation of beta-sitosterol, beta-sitosteryl-3beta-glucopyranoside, beta-sitosteryl-3beta-glucopyranoside-6'-O-palmitate (1), lupenone, lupeol acetate, plumbagin and trilinolein. Compound 1 showed cytotoxic activity against MCF7 and Bowes cancer cell lines (IC50 113 microM and 152 microM, respectively), beta-sitosterol inhibited Bowes cell growth (IC50 36.5 microM) and plumbagin was cytotoxic against MCF7 and Bowes cells (IC50 1.28 microM and 1.39 microM, respectively).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / administration & dosage
Antineoplastic Agents, Phytogenic / pharmacology*
Antineoplastic Agents, Phytogenic / therapeutic use
Cell Line, Tumor / drug effects
Humans
Inhibitory Concentration 50
Phytotherapy*
Plant Components, Aerial
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Plumbaginaceae*

Substances

Antineoplastic Agents, Phytogenic
Plant Extracts