Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

Tomomi Noguchi; Hiroko Sano; Rumiko Shimazawa; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1016/j.bmcl.2004.06.026

Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4141-5. doi: 10.1016/j.bmcl.2004.06.026.

Authors

Tomomi Noguchi¹, Hiroko Sano, Rumiko Shimazawa, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Affiliation

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

PMID: 15261258
DOI: 10.1016/j.bmcl.2004.06.026

Abstract

Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Magnetic Resonance Spectroscopy
Nitric Oxide Synthase / antagonists & inhibitors*
Phthalimides / chemistry
Phthalimides / pharmacology*
Thalidomide / chemistry
Thalidomide / pharmacology*

Substances

Enzyme Inhibitors
Phenylhomophthalimide
Phthalimides
Thalidomide
Nitric Oxide Synthase