Abstract
Those factors that determine whether tissue injury is followed by regeneration and repair or irreversible destruction and fibrosis are only now being elucidated. This article examines the lung's response to injury, the prominent role of polypeptide growth factors and cytokines in directing tissue responses, and the effects of injury on cell-specific expression of a number of genes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Bronchopulmonary Dysplasia / etiology
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Bronchopulmonary Dysplasia / pathology
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Bronchopulmonary Dysplasia / physiopathology
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Fibrosis
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Gene Expression
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Growth Substances / biosynthesis
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Growth Substances / physiology
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Humans
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Infant, Newborn
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Inflammation
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Lung Diseases / chemically induced
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Lung Diseases / pathology*
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Lung Diseases / physiopathology
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Oxygen / adverse effects*
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Wound Healing