Patient-specific seizure onset detection

Epilepsy Behav. 2004 Aug;5(4):483-98. doi: 10.1016/j.yebeh.2004.05.005.

Abstract

This article presents an automated, patient-specific method for the detection of epileptic seizure onset from noninvasive electroencephalography. We adopt a patient-specific approach to exploit the consistency of an individual patient's seizure and nonseizure electroencephalograms. Our method uses a wavelet decomposition to construct a feature vector that captures the morphology and spatial distribution of an electroencephalographic epoch, and then determines whether that vector is representative of a patient's seizure or nonseizure electroencephalogram using the support vector machine classification algorithm. Our completely automated method was tested on noninvasive electroencephalograms from 36 pediatric subjects suffering from a variety of seizure types. It detected 131 of 139 seizure events within 8.0+/-3.2 seconds of electrographic onset, and declared 15 false detections in 60 hours of clinical electroencephalography. Our patient-specific method can be used to initiate delay-sensitive clinical procedures following seizure onset, for example, the injection of a functional imaging radiotracer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Diagnosis, Computer-Assisted / methods
  • Electroencephalography / classification
  • Electroencephalography / methods*
  • Electroencephalography / statistics & numerical data
  • Epilepsy / diagnosis*
  • Epilepsy / physiopathology
  • Humans
  • Monitoring, Physiologic / methods
  • Reaction Time / physiology
  • Signal Processing, Computer-Assisted / instrumentation
  • Time Factors