Efficient acyclic stereocontrol using the tethered aminohydroxylation reaction

Timothy J Donohoe; Peter D Johnson; Richard J Pye; Martine Keenan

doi:10.1021/ol049136i

Efficient acyclic stereocontrol using the tethered aminohydroxylation reaction

Org Lett. 2004 Jul 22;6(15):2583-5. doi: 10.1021/ol049136i.

Authors

Timothy J Donohoe¹, Peter D Johnson, Richard J Pye, Martine Keenan

Affiliation

¹ Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK. tiothy.donohoe@chem.ox.ac.uk

PMID: 15255696
DOI: 10.1021/ol049136i

Abstract

[reaction: see text] The tethered aminohydroxylation (TA) of acyclic allylic carbamates has been achieved in a stereospecific and stereoselective manner. Unusually high levels of stereocontrol were observed in the oxidation of 1,1-disubstituted substrates.