A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis

M Eugenio Vazquez; Deborah M Rothman; Barbara Imperiali

doi:10.1039/b408001g

A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis

Org Biomol Chem. 2004 Jul 21;2(14):1965-6. doi: 10.1039/b408001g. Epub 2004 Jun 22.

Authors

M Eugenio Vazquez¹, Deborah M Rothman, Barbara Imperiali

Affiliation

¹ Departments of Chemistry and Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

PMID: 15254619
DOI: 10.1039/b408001g

Abstract

A new 4-(N,N-dimethylamino) phthalimide-based environment-sensitive fluorescent building block for solid phase peptide synthesis, has been synthesized and incorporated into peptides. Peptides incorporating this residue show great potential for biological applications in sensing protein/protein interactions.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Amino Acids / chemistry*
Fluorenes / chemistry*
Fluorescent Dyes / chemistry*
Molecular Structure
Peptides / chemical synthesis*
Peptides / chemistry
Phthalimides / chemical synthesis
Phthalimides / chemistry

Substances

4-(N,N-dimethylamino) phthalimide
Amino Acids
Fluorenes
Fluorescent Dyes
N(alpha)-fluorenylmethyloxycarbonylamino acids
Peptides
Phthalimides

Grants and funding

GM64346/GM/NIGMS NIH HHS/United States