Abstract
The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chlorocebus aethiops
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Glyceraldehyde-3-Phosphate Dehydrogenases / genetics
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Herpesvirus 1, Human / physiology*
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Mice
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Neurons / metabolism*
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RNA / metabolism*
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Ribonucleases
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Vero Cells
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Viral Proteins / physiology*
Substances
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Viral Proteins
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virion host shutoff protein, Simplexvirus
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RNA
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Glyceraldehyde-3-Phosphate Dehydrogenases
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Ribonucleases