The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons

J Virol. 2004 Aug;78(15):8400-3. doi: 10.1128/JVI.78.15.8400-8403.2004.

Abstract

The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chlorocebus aethiops
  • Glyceraldehyde-3-Phosphate Dehydrogenases / genetics
  • Herpesvirus 1, Human / physiology*
  • Mice
  • Neurons / metabolism*
  • RNA / metabolism*
  • Ribonucleases
  • Vero Cells
  • Viral Proteins / physiology*

Substances

  • Viral Proteins
  • virion host shutoff protein, Simplexvirus
  • RNA
  • Glyceraldehyde-3-Phosphate Dehydrogenases
  • Ribonucleases