Putting a brake on an autonomous DNA nanomotor

J Am Chem Soc. 2004 Jul 21;126(28):8626-7. doi: 10.1021/ja047991r.

Abstract

A strategy was developed to reversibly switch on/off an autonomous DNA nanomotor that contains a DNA enzyme. The multiple RNA cleavage of the DNAzyme powered the motor to move, and a strand displacement mechanism provided the basis for a reversible brake to the motor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA / chemistry*
  • DNA / drug effects*
  • DNA / physiology
  • Molecular Motor Proteins / chemistry*
  • Molecular Motor Proteins / drug effects*
  • Molecular Motor Proteins / physiology
  • Nanotechnology / methods*
  • Nucleic Acids / pharmacology*
  • Spectrometry, Fluorescence

Substances

  • Molecular Motor Proteins
  • Nucleic Acids
  • DNA