Abstract
Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with the known compounds julocrotonine (4), lichexanthone (5) and selin-11-en-4alpha-ol (6). The structures of the new compounds were established by spectral methods. The in vitro cytotoxic activity of Compounds 1-6 was evaluated against six human tumor cells lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor / drug effects
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Croton*
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Humans
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Magnetic Resonance Spectroscopy
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Phytotherapy*
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Piperidones / chemistry
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Piperidones / pharmacology
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Plant Components, Aerial
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology*
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Piperidones
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Plant Extracts
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glutarimide