First-degree heart block in the fetus of an anti-SSA/Ro-positive mother: reversal after a short course of dexamethasone treatment

Arthritis Rheum. 2004 Jul;50(7):2223-6. doi: 10.1002/art.20341.

Abstract

Isolated congenital heart block is almost invariably associated with the presence of antibodies to SSA/Ro and SSB/La antigens in the maternal circulation. Once established, third-degree congenital heart block is permanent. However, a lesser degree of autoantibody-associated heart block in a fetus can be reversed if it is recognized and treated early enough with fluorinated glucocorticosteroids. The only method available clinically for the recognition of first-degree heart block in a fetus is measurement of the mechanical PR interval by pulsed Doppler echocardiography. This is the first report of a fetus in whom a diagnosis of first-degree heart block and the consequent decision to intervene were based solely on this technique. In addition, the first-degree heart block resolved completely after only 2 weeks of dexamethasone treatment, and the heart rhythm remained stable throughout the remainder of the pregnancy despite early discontinuation of therapy due to oligohydramnios.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Antinuclear / blood*
  • Dexamethasone / therapeutic use*
  • Echocardiography, Doppler, Pulsed
  • Female
  • Fetal Heart*
  • Glucocorticoids / therapeutic use*
  • Heart Block / diagnostic imaging
  • Heart Block / drug therapy*
  • Humans
  • Pregnancy / blood
  • Pregnancy / immunology*
  • Treatment Outcome
  • Ultrasonography, Prenatal

Substances

  • Antibodies, Antinuclear
  • Glucocorticoids
  • SS-A antibodies
  • Dexamethasone