Abstract
Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.
MeSH terms
-
Animals
-
Antigen Presentation / immunology*
-
Antigen-Presenting Cells / immunology*
-
Antigens, CD / immunology*
-
Autoimmune Diseases / immunology
-
Bacteria / immunology*
-
Bacterial Infections / immunology*
-
Bacterial Infections / microbiology
-
Bacterial Infections / pathology
-
Heat-Shock Proteins / immunology*
-
Humans
-
Lymphocyte Activation / immunology
-
Membrane Glycoproteins / immunology
-
Mice
-
Receptors, Cell Surface / immunology
-
T-Lymphocytes / immunology
-
Toll-Like Receptors
Substances
-
Antigens, CD
-
Heat-Shock Proteins
-
Membrane Glycoproteins
-
Receptors, Cell Surface
-
Toll-Like Receptors