Heat-shock proteins and the host-pathogen interaction during bacterial infection

Curr Opin Immunol. 2004 Aug;16(4):506-10. doi: 10.1016/j.coi.2004.05.007.

Abstract

Heat-shock proteins (HSPs) are expressed at high levels by bacterial pathogens during adaptation to intracellular survival. Both host and pathogen heat-shock proteins contribute to immunity by receptor-mediated activation of the innate immune response and by participation in the presentation of antigens for the adaptive immune response. Manipulation of these interactions presents a potential route to improved control of infection by vaccination or immunotherapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Antigen-Presenting Cells / immunology*
  • Antigens, CD / immunology*
  • Autoimmune Diseases / immunology
  • Bacteria / immunology*
  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Bacterial Infections / pathology
  • Heat-Shock Proteins / immunology*
  • Humans
  • Lymphocyte Activation / immunology
  • Membrane Glycoproteins / immunology
  • Mice
  • Receptors, Cell Surface / immunology
  • T-Lymphocytes / immunology
  • Toll-Like Receptors

Substances

  • Antigens, CD
  • Heat-Shock Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors