A global bifurcation of the blue sky catastrophe type has been found in a small Prandtl number binary mixture contained in a laterally heated cavity. The system has been studied numerically applying the tools of bifurcation theory. The catastrophe corresponds to the destruction of an orbit which, for a large range of Rayleigh numbers, is the only stable solution. This orbit is born in a global saddle-loop bifurcation and becomes chaotic in a period-doubling cascade just before its disappearance at the blue sky catastrophe.