Abstract
Abrogation of the endothelial cell-specific semaphorin receptor PlexinD1 in zebrafish and mouse reveals semaphorin functions selectively affecting the cardiovascular system. Neuropilins team up with PlexinD1 to form a novel endothelial receptor complex for class 3 semaphorins.
MeSH terms
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Animals
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Cardiovascular Abnormalities / genetics
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Cardiovascular Abnormalities / metabolism
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Cardiovascular System / cytology
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Cardiovascular System / embryology*
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Cardiovascular System / metabolism
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Endothelium, Vascular / abnormalities*
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Endothelium, Vascular / cytology
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Endothelium, Vascular / metabolism
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Gene Expression Regulation, Developmental / genetics
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Humans
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Intracellular Signaling Peptides and Proteins
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Membrane Glycoproteins / deficiency*
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Membrane Glycoproteins / genetics
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Models, Animal
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Nerve Tissue Proteins / deficiency*
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Nerve Tissue Proteins / genetics
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Neuropilins / metabolism
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Semaphorins / metabolism*
Substances
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Intracellular Signaling Peptides and Proteins
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Neuropilins
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Plxnd1 protein, mouse
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Semaphorins