Semaphorins guide PerPlexeD endothelial cells

Dev Cell. 2004 Jul;7(1):1-2. doi: 10.1016/j.devcel.2004.06.012.

Abstract

Abrogation of the endothelial cell-specific semaphorin receptor PlexinD1 in zebrafish and mouse reveals semaphorin functions selectively affecting the cardiovascular system. Neuropilins team up with PlexinD1 to form a novel endothelial receptor complex for class 3 semaphorins.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cardiovascular Abnormalities / genetics
  • Cardiovascular Abnormalities / metabolism
  • Cardiovascular System / cytology
  • Cardiovascular System / embryology*
  • Cardiovascular System / metabolism
  • Endothelium, Vascular / abnormalities*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • Gene Expression Regulation, Developmental / genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Membrane Glycoproteins / deficiency*
  • Membrane Glycoproteins / genetics
  • Models, Animal
  • Nerve Tissue Proteins / deficiency*
  • Nerve Tissue Proteins / genetics
  • Neuropilins / metabolism
  • Semaphorins / metabolism*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Neuropilins
  • Plxnd1 protein, mouse
  • Semaphorins