Abstract
Background:
The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level.
Results:
We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods.
Conclusions:
The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence / genetics
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Animals
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Apoptosis / genetics*
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Arabidopsis Proteins / chemistry
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Arabidopsis Proteins / genetics
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Caenorhabditis elegans Proteins / chemistry
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Caenorhabditis elegans Proteins / genetics
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Conserved Sequence / genetics
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Drosophila Proteins / chemistry
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Drosophila Proteins / genetics
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Humans
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Molecular Sequence Data
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Neoplasms / genetics*
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Peptides / chemistry
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Peptides / genetics*
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Plasmodium / genetics
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Protein Structure, Tertiary / genetics
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Proteins / chemistry
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Proteins / genetics
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Protozoan Proteins / chemistry
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Protozoan Proteins / genetics
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Saccharomyces cerevisiae Proteins / chemistry
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Saccharomyces cerevisiae Proteins / genetics
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Sequence Homology, Amino Acid
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Signal Recognition Particle / genetics*
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Transcription, Genetic / genetics*
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Xenopus Proteins / chemistry
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Xenopus Proteins / genetics
Substances
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Arabidopsis Proteins
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Caenorhabditis elegans Proteins
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Drosophila Proteins
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Peptides
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Proteins
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Protozoan Proteins
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Saccharomyces cerevisiae Proteins
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Signal Recognition Particle
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Xenopus Proteins