A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children

AIDS. 2004 Jul 23;18(11):1598-600. doi: 10.1097/01.aids.0000131363.82951.fb.

Abstract

In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Gene Frequency
  • HIV Infections / genetics*
  • HIV-1*
  • Humans
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors
  • beta-Defensins / genetics*

Substances

  • DEFB1 protein, human
  • beta-Defensins