A mathematical formulation for the cell-cycle model in somitogenesis: analysis, parameter constraints and numerical solutions

Math Med Biol. 2004 Jun;21(2):85-113. doi: 10.1093/imammb/21.2.85.

Abstract

In this work we present an analysis, supported by numerical simulations, of the formulation of the cell-cycle model for somitogenesis proposed in Collier et al. (J. Theor Biol. 207 (2000), 305-316). The analysis indicates that by introducing appropriate parameter constraints on model parameters the cell-cycle mechanism can indeed give rise to the periodic pattern of somites observed in normal embryos. The analysis also provides a greater understanding of the signalling process controlling somite formation and allows us to understand which parameters influence somite length.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Chick Embryo
  • Embryonic Development / physiology*
  • Models, Biological*
  • Numerical Analysis, Computer-Assisted
  • Somites / cytology
  • Somites / physiology*