Abstract
The use of toxins as novel molecular probes to study the structure-function relationship of ion-channels and receptors as well as potential therapeutics in the treatment of wide variety of diseases is well documented. The high specificity and selectivity of these toxins have attracted a great deal of interest as candidates for drug development. This review highlights the involvement of the proteins and peptide toxins as well as non-proteinaceous compounds derived from both venomous and non-venomous animals, in anti-nociception and anti-inflammation. The possible mechanisms of these potential therapeutic agents and possible clinical applications in the treatment of pain and inflammation are also summarized.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amphibian Venoms / metabolism
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Amphibian Venoms / therapeutic use
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Analgesics / metabolism*
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Analgesics / therapeutic use
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Animals
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Anti-Inflammatory Agents / metabolism*
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Anti-Inflammatory Agents / therapeutic use
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Conotoxins / metabolism
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Conotoxins / therapeutic use
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Molecular Probe Techniques
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Phospholipases A / antagonists & inhibitors
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Pyridines / chemistry
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Scorpion Venoms / metabolism
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Scorpion Venoms / therapeutic use
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Snake Venoms / metabolism
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Snake Venoms / therapeutic use
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Spider Venoms / metabolism
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Spider Venoms / therapeutic use
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Structure-Activity Relationship
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Toxins, Biological / metabolism*
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Toxins, Biological / therapeutic use*
Substances
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Amphibian Venoms
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Analgesics
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Anti-Inflammatory Agents
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Bridged Bicyclo Compounds, Heterocyclic
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Conotoxins
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Pyridines
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Scorpion Venoms
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Snake Venoms
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Spider Venoms
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Toxins, Biological
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Phospholipases A
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epibatidine