This study compared the effects of 2 treatment protocols for correcting Class II disharmony. The first phase of treatment consisted of functional jaw orthopedics with either the Twin-block or the stainless-steel crown Herbst appliance; the second phase consisted of comprehensive fixed-appliance therapy in both protocols. Each of the 2 samples comprised 28 consecutively treated Class II patients. The mean age at the start of treatment was approximately 12 years, and the mean age at the end of the treatment was approximately 14.5 years in both groups. The duration of the treatment phase with the functional appliance was approximately 13 months, and the duration of fixed-appliance therapy was approximately 15 months in both groups. The sex distribution was identical in the 2 groups. Lateral cephalograms were analyzed at the start of treatment (T1) and at the end of the overall treatment protocol (T2). Nonparametric statistics were used for comparisons of starting forms and of the T1-T2 changes between the 2 treatment groups. The stainless-steel crown Herbst appliance and the Twin-block appliance produced very similar therapeutic modifications in Class II patients, although the Twin-block group exhibited almost 2 mm greater correction of the maxillomandibular differential than did the crown Herbst group. The treatment effects of both protocols led to a normalization of the dentoskeletal parameters at the end of the overall treatment period. Twin-block therapy also induced a greater increase in the height of the mandibular ramus (posterior facial height). Overall, only minor differences were detected in the treatment and posttreatment effects of a compliance-free (crown Herbst) and a noncompliance-free (Twin-block) appliance for correcting Class II disharmony.