The 3' cis-acting genomic replication element of the severe acute respiratory syndrome coronavirus can function in the murine coronavirus genome

J Virol. 2004 Jul;78(14):7846-51. doi: 10.1128/JVI.78.14.7846-7851.2004.

Abstract

The 3' untranslated region (3' UTR) of the genome of the severe acute respiratory syndrome coronavirus can functionally replace its counterpart in the prototype group 2 coronavirus mouse hepatitis virus (MHV). By contrast, the 3' UTRs of representative group 1 or group 3 coronaviruses cannot operate as substitutes for the MHV 3' UTR.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3' Untranslated Regions / genetics*
  • Animals
  • Base Sequence
  • Enhancer Elements, Genetic*
  • Genome, Viral
  • Humans
  • Mice
  • Molecular Sequence Data
  • Murine hepatitis virus / genetics*
  • Recombination, Genetic*
  • Severe acute respiratory syndrome-related coronavirus / genetics*
  • Virus Replication*

Substances

  • 3' Untranslated Regions