Washing-free electrochemical DNA detection using double-stranded probes and competitive hybridization reaction

Chem Commun (Camb). 2004 Jul 7:(13):1466-7. doi: 10.1039/b402914c. Epub 2004 May 28.

Abstract

A new electrochemical DNA detection method using double-stranded probes and competitive hybridization reaction offers highly selective discrimination of single base mismatch without post-hybridization washing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pair Mismatch
  • DNA / analysis*
  • DNA / chemistry
  • DNA Probes*
  • Electrochemistry / methods*
  • Nucleic Acid Hybridization
  • Oligonucleotide Array Sequence Analysis / methods
  • Polymerase Chain Reaction

Substances

  • DNA Probes
  • DNA