Abstract
In vitro activities of ABT-492, ciprofloxacin, levofloxacin, trovafloxacin, moxifloxacin, gatifloxacin, and gemifloxacin were compared. ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. Bactericidal activity of ABT-492 was also evaluated.
MeSH terms
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Anti-Infective Agents / pharmacology*
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Bacterial Proteins / metabolism
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Carrier Proteins / metabolism
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Fluoroquinolones / pharmacology
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Gram-Negative Bacteria / drug effects*
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Gram-Negative Bacteria / genetics
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Gram-Positive Bacteria / drug effects*
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Gram-Positive Bacteria / genetics
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Hexosyltransferases / metabolism
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Kinetics
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Microbial Sensitivity Tests
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Muramoylpentapeptide Carboxypeptidase / metabolism
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Penicillin Resistance
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Penicillin-Binding Proteins
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Peptidyl Transferases / metabolism
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Quinolones / pharmacology*
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Vancomycin Resistance
Substances
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Anti-Infective Agents
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Bacterial Proteins
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Carrier Proteins
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Fluoroquinolones
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Penicillin-Binding Proteins
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Quinolones
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delafloxacin
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase